The flights will link Edinburgh Airport and Boston's Logan International Airport from 24 May. The seasonal route will be operated by US airline Delta, alongside its existing service to New York, in conjunction with Virgin Atlantic.
North America has been one of our biggest growth markets...to add Boston with Delta is fantastic news...Gordon Dewar, Chief Executive, Edinburgh Aiport
The Scottish government has welcomed the announcement. Transport Secretary Michael Matheson highlighted the "important role" that direct air links between the US and Scotland had in the Scottish economy.
He said: "Not only will this give Scottish businesses a direct route into important North American markets, but it will also give inbound visitors more options when it comes to getting a taste of the world-class tourism experience on offer in Scotland."
There will be two flights every day on the new route during peak summer months. Malcolm Roughead, chief executive of VisitScotland, also welcomed the strengthened links with the US market. He said: "It is exciting that this new service from Boston to Edinburgh will open up opportunities for the Scottish tourism industry to engage with a new area of the USA".
Roberto Ioriatti, Delta's vice president - transatlantic, said: "Boston is our fastest-growing international hub and a daily service from Edinburgh responds to increased demand for travel to the US and provides greater choice when it comes to planning trips for business or pleasure."
More than half a million American tourists visited Scotland in 2017, and the new route will add a further 2,000 seats per week between the US and Scotland...